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5 achievements of Professor Raphael Mechoulam

Professor Mechoulam’s career spanned six decades, across which he dedicated himself to understanding the chemical makeup of cannabis and exploring its potential as a medicine. In tribute to Professor Raphael Mechoulam, the world-renowned Israeli organic chemist whose contribution to medical cannabis development was indisputable, we explore 5 of his achievements.

Professor Raphael Mechoulam is his laboratory black and white

1. Discovery of THC

In 1964, Professor Mechoulam isolated delta-9-tetrahydrocannabinol (THC), the psychoactive compound in cannabis that produces the “high” many associate with the recreational use of cannabis. This discovery paved the way for further research into the therapeutic properties of cannabis and the development of synthetic THC-based medications.

Professor Mechoulam is often referred to as ‘the father of cannabis research,’ and for good reason.

2. Identification of the Endocannabinoid System

In the late 1980s and early 1990s, Professor Mechoulam and his team discovered the endocannabinoid system, a complex network of receptors and signalling molecules that regulate a wide range of physiological processes. The ECS is a complex system of receptors, endocannabinoids, and enzymes that are involved in regulating various physiological processes, including pain, appetite, mood, and immune function. This groundbreaking discovery has led to the development of new drugs for a variety of medical conditions, including chronic pain, multiple sclerosis, and epilepsy.

3. Exploration of Cannabidiol (CBD)

Professor Mechoulam has been a pioneer in the study of cannabidiol (CBD), a non-psychoactive compound found in cannabis. His research has shown that CBD has significant therapeutic potential. The benefits of CBD research have found it supports the body across pain relief, anxiety and depression, epilepsy, sleep and various skin conditions. Professor Mechoulam also played a key role in the development of Epidiolex, the first FDA-approved CBD-based medication for the treatment of epilepsy.

4. Investigation of Cannabinoid Chemistry

Professor Mechoulam has dedicated much of his career to exploring the chemistry of cannabinoids, the active compounds found in cannabis. Cannabis is an incredibly complex plant, with more than 550 chemical compounds and over 100 phytocannabinoids. Professor Mechoulam’s work has led to the discovery of numerous cannabinoids, including cannabigerol (CBG) and tetrahydrocannabivarin (THCV), and has helped to unlock the full potential of cannabis as a medicine.

5. Advocacy for Cannabis Research

Throughout his career, Professor Mechoulam has been a passionate advocate for cannabis research and legalisation. He has argued that the stigma surrounding cannabis has hindered scientific progress and has called for a more rational and evidence-based approach to drug policy. His tireless efforts have helped to elevate the study of cannabis to a legitimate field of scientific inquiry.

In conclusion, Professor Raphael Mechoulam is a true pioneer in the field of cannabis research. His groundbreaking discoveries have helped to unlock the potential of cannabis as a medicine, and his advocacy has helped to push the field forward. As the world continues to explore the therapeutic potential of cannabis, Professor Mechoulam’s work will remain a cornerstone of this important field of study.

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