The five best terpenes for anxiety relief

A study by Mamedica reveals that an overwhelming 42% of UK adults have been living with severe anxiety for several years and are yet to find an effective remedy. While pharmaceutical options exist, many individuals seek natural alternatives for relief. 

Terpenes are a diverse group of organic compounds present in various plants, including cannabis. They have been known to provide beneficial effects for those living with a range of chronic conditions including anxiety, as they have a synergistic effect on the body. This is because terpene can interact with our endocannabinoid system and regulate your mood, sleep, and appetite. In this blog, we delve into five of the best terpenes known for their anxiety-reducing properties.

Terpenes - Linalool


Linalool is a terpene commonly found in lavender, mint, and some strains of cannabis. It is best known for its floral aroma and is a staple in aromatherapy.

How It Helps with Anxiety

Linalool has been found to exhibit anxiolytic (anxiety-reducing) properties. It works by affecting the body’s neurotransmitters, particularly by enhancing the effects of serotonin, a key neurotransmitter involved in mood regulation. A study conducted demonstrated that linalool exposure reduced anxiety-like behaviors in mice. 


Myrcene is the most abundant terpene in many cannabis strains and is also found in hops, thyme, and lemongrass. It has a musky, earthy aroma.

How It Helps with Anxiety

Myrcene is known for its sedative effects. A study highlighted myrcene’s ability to enhance sleep and relax muscles, which can indirectly alleviate anxiety by promoting overall relaxation and reducing stress. Another study revealed that Myrcene reduced inflammation indicating its potential to alleviate anxiety and stress and promote restfulness.

terpenes - caryophyllene


Caryophyllene is found in black pepper, cloves, and cannabis. It has a spicy, woody aroma and is unique among terpenes because it acts as a cannabinoid, directly interacting with CB2 receptors in the endocannabinoid system.

How It Helps with Anxiety

Caryophyllene’s interaction with the CB2 receptors makes it effective in reducing inflammation and anxiety. A study published in Physiology & Behavior found that this terpene produces anxiolytic effects by modulating the body’s response to stress. Another study in the Journal of Psychopharmacology showed that beta-caryophyllene could reduce anxiety and depressive behaviors, suggesting it could be a potent natural remedy for anxiety.


Limonene is abundant in citrus fruits like lemons, oranges, and limes, and gives them their characteristic zesty smell. It is also present in various cannabis strains.

How It Helps with Anxiety

Limonene is known for its mood-enhancing properties. It has been shown to elevate serotonin levels in the brain, which can help reduce anxiety and depression. study in Advances in Pharmacological Sciences indicated that limonene could exert anti-anxiety effects by modulating neurotransmitter activity. A notable study by Johns Hopkins University explored the effects of vaporized d-limonene, both alone and in combination with THC, on anxiety. The researchers found that combining d-limonene with THC significantly reduced feelings of anxiety and paranoia compared to THC alone. This reduction was dose-dependent, with higher doses of limonene producing greater reductions in anxiety symptoms​. 

terpenes - Terpinolene


Terpinolene is less common than the other terpenes mentioned but is found in apples, lilacs, tea trees, and certain cannabis strains. It has a fresh, herbal, and slightly citrusy aroma.

How It Helps with Anxiety

Terpinolene is known for its sedative effects. A study found that terpinolene exhibited significant sedative properties, which can help in reducing anxiety by promoting a state of calm and relaxation. Its ability to act on the central nervous system suggests a calming effect that can be beneficial for those experiencing anxiety.

How do I know which to look out for?

By understanding the effects of the common cannabis terpenes, you can identify which strain is most beneficial for your needs with a specialist consultant. 

At Mamedica, we offer one-to-one consultations with our specialist doctors during which your bespoke treatment plan will be determined

During this initial assessment, our specialists will understand your pain and health concerns to ensure your medical cannabis treatment is stress-free, simple, safe, and effective. Check your eligibility for treatment here.  

Now you know what terpene is and why it matters, remember to keep an eye on our blog as we share everything you need to know about the three main cannabis terpenes in the upcoming weeks.